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KMID : 0380020090240040397
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Korean Journal of Biotechnology and Bioengineering
2009 Volume.24 No. 4 p.397 ~ p.402
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The Melanin Inhibition, Anti-aging and Anti-inflammation Effects of Portulaca oleracea Extracts on Cells
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Zhang Rui
An Sung-Kwan
Lee Hyun-Jin
Yoon Yeong-Min
Kim Su-mi
Kim Hyun-Sook
Li Shun-Hua
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Abstract
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The Portulaca oleracea (P. oleracea) is a popular herbal medicine in East Asia that was known to possess detoxification, antifebrile and antifungal effects. In the present study, we examined the biological activities of ethanol extracts of P. oleracea under various conditions with NIH3T3, B16F10, and MCF-7 cell line model systems. Extracts of P. oleracea (0.5 mg/ml) showed inhibition of expression of tyrosinase, but does not suppress either of TYRP-1 or DCT expression on B16F10 cells. Extracts of P. oleracea (2 mg/ml) showed anti-inflammatory effects on TNF--stimulated NIH3T3/-Luc cells and increase of the synthesis of collagen on NIH3T3 (wild type) cells. These results suggest that extracts of P. oleracea could be used as a functional biomaterial in developing a skin whitening agent and having the anti-inflammatory, anti-wrinkle, and anti-aging activities.
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KEYWORD
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Portulaca oleracea, tyrosinase, collagen, anti-inflammation, anti-aging
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